![]() This brief section on heredity may answer some of your questions about what causes osteogenesis imperfecta. pale blue sclerae at birth that become white by adulthood.In OI type IV most fractures occur during childhood but women often have a recurrence of fractures after menopause. OI type IV is inherited in an autosomal dominant pattern although some people have the disorder as a result of a new dominant mutation. short stature (some people may only grow to be three feet tall).mild to severe hearing loss in adult life.poor development of the teeth (dentinogenesis imperfecta) causing teeth to be discolored and to break easily.severely misshapen chest that may cause problems with breathing.compressed vertebrae and severe curvature of the spine (scoliosis).soft bones that not only break but also bend easily.Loose joints and poor muscle development are common. It is not unusual for a person to have 20 or more fractures occurring during the first three years of life and more than 100 fractures by puberty. These people often have many spontaneous fractures. It usually results from a new dominant mutation. OI Type IIIĪpproximately 20 percent of people with OI have OI type III. Infants with this form of OI have fractures before birth have extremely fragile bones and usually die shortly after birth. hearing loss beginning in the teens, twenties, or thirtiesĪbout 10 percent of people with OI have OI type II.blue sclerae (the white part of the eye).People with OI type I have one or more of the following features: People with OI type I have an average of 20 to 40 fractures before puberty. It is inherited in an autosomal dominant pattern but may occur as a result of a spontaneous mutation. The skin cells are grown in culture and the collagen is studied. This involves removing a tiny piece of skin, usually from the back of the arm. The diagnosis of the type of OI is made based upon information obtained from the person's physical examination, family history, and X-ray studies. For example, a parent with OI type IV will not have a child with OI type III. The type of OI is consistent or "runs true in a family. There are four distinct types of OI: types I, II, III, and IV. Increased awareness can not only can help promote a better understanding of OI, but also can reduce the risk of misdiagnosis resulting in mistaken accusations of child abuse. Another purpose is to increase public awareness about this condition. The main purpose of this page is to provide background information about the diagnosis and treatment of OI. While there is no cure for OI early diagnosis and treatment can help ease symptoms and prevent complications. Most often they can attend regular schools enjoy a wide range of career and lifestyle choices experience fulfilling relationships and have children. Most people with OI have a normal life expectancy and lead very productive lives. There are several types of collagen and one of the most important is type I collagen. Collagen is the protein ""glue"" that holds the body's tissues together and gives strength to bones. OI results from an alteration either in the chemical makeup or production of collagen. Osteogenesis Imperfecta (OI) is a group of inherited disorders in which the most common feature is bones that break easily. Orthopaedics and Sports Medicine Bulletin. ![]() Resident Research - Intake and Travel Award Forms.Orthopaedic Surgery and Sports Medicine Interest Group.Residents Portal and Digital Curriculum.
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